Clinically Studied Longevity Formula

NOVOS Core

NOVOS Core

 (1,331 Reviews)
$89.00
$89.00 $109.00
SAVE 18% Sold out

Support the biology of a longer, healthier life.*
All-In-One Longevity System. Our clinically studied foundational daily formulation supporting whole-body health at the system level.

check All-day energy, no crash*

check Supportfor restful sleep*

check Clinically studied cardiovascular support*

check Firmer, healthier-looking skin**

check Total-body longevity, one daily drink*

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NOVOS Core

NOVOS Core

$89.00
$89.00 $109.00
SAVE 18% Sold out

Clinically evaluated benefits

NOVOS Core is designed to target all 12 Hallmarks of Aging. Its finished formula was studied in a randomized, double-blind, placebo-controlled human trial in healthy adults aged 40+, which showed benefits to cardiovascular aging markers. In a separate customer survey, 81% of NOVOS customers feel a difference within 2 weeks in sleep, mood, energy & skin. Preliminary results; manuscript under peer review. Survey results are self-reported. Individual results may vary.

Key ingredients

All 12 longevity ingredients in one daily serving, including Calcium Alpha-Ketoglutarate, Fisetin, Pterostilbene, Glycine, Magnesium Malate, L-Theanine and Micro-dosed Lithium. No proprietary blends – every dose disclosed.

How to use

Mix one sachet into water once a day. Dissolves easily. Most customers take NOVOS Core in the morning, though some prefer the evening, since better sleep is one of the changes customers mention most. Consistency matters more than the time of day.

Clean formulation

Sugar-free, vegan, gluten-free. No artificial sweeteners. Manufactured in the USA in a cGMP facility and third-party tested.

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  • 1. Healthy aging

    Designed to target all 12 root causes of aging at once.

  • 2. Improved skin

    All pilot-study participants improved skin firmness.

  • 3. Better energy & recovery

    Steadier, day-long energy. No caffeine, no crash.

  • 4. Improved sleep

    Formulated with ingredients associated with restful sleep.

  • 5. Cardiovascular health

    Rapid, durable support shown in a placebo- controlled human trial.

    81% of NOVOS customers feel a difference within 2 weeks.*

    81% of NOVOS customers feel a difference within 2 weeks.*

    *Based on a self-reported customer survey across six areas of daily wellbeing (skin, mood, cognition, energy, sleep, overall wellbeing). Individual results may vary.

    Real Stories. Real Results.

      Based on epigenetic biological age testing. Results are approximations of biological aging. Individual results may vary.

      Developed with doctors and scientists from Harvard, MIT, and more. 

      More good years. Starting now. 

      NOVOS Core works on the biology of aging, with effects clinically shown to build from the first dose. 

      • From the first dose

        Cardiovascular function responds right away
        In a randomized, double-blind, placebo- controlled trial in healthy adults aged 40+, conducted at the University of Surrey, NOVOS Core showed benefits to cardiovascular function shortly after the very first dose.

      • Within days

        A calmer, more rested feeling
        NOVOS Core includes Glycine, an amino acid studied in connection with falling asleep more easily and feeling more refreshed in the morning, and L-Theanine, studied in connection with calm, steady focus.

      • The first few weeks

        81% feel a difference at 2 weeks
        Many customers report steadier energy and a calmer, more rested feeling after two weeks of daily use. NOVOS Core includes Rhodiola rosea, an adaptogen studied for its potential to support stamina, and magnesium, a cofactor in cellular energy production.

      • The first few months

        Skin, focus, and overall well-being
        Skin, focus, and an overall sense of well-being are the changes customers mention building over the first months.

      • By six months

        Longevity biomarkers improved vs.placebo
        In a double-blind, placebo-controlled trial in healthy adults aged 40+, NOVOS Core showed benefits to cardiovascular aging markers at six months: blood vessel flexibility, circulation, and blood pressure (for blood pressures already in the normal range).

      • Beyond six months

        73% improved their pace of aging score
        In a case study, a majority of participants slowed their biological pace of aging after using NOVOS Core + Boost daily for 6 months, as measured by the DunedinPACE epigenetic test.

        What sets NOVOS Core apart.

        How NOVOS Core compares across the benefits that matter most.

        Most “Longevity Supplements” Are Not Actually Longevity Supplements

        And are never tested as the product you actually take.

        In a randomized, double-blind, placebo-controlled human trial, the complete NOVOS Core formulation provided nutritional support for biological systems predictive of lifespan and healthspan.*

        That’s the difference between claiming longevity and demonstrating measurable results.

        “This trial provides rare human evidence that a multi-pathway nutritional strategy can meaningfully influence cardiovascular aging biology itself.”

        Dr. Christian Heiss

        Professor of Cardiovascular Medicine, University of Surrey

        • Blood Flow

          Flow-mediated dilation

          How well your arteries open when your body needs more blood. In the trial, FMD improved +2.9% vs placebo — a leading marker of endothelial and vascular health.

        • Blood Vessel Flexibility

          Pulse wave velocity

          How flexible your arteries are. PWV typically worsens about 1 m/s per decade; the trial showed a 1.2 m/s improvement vs placebo.

        • Blood Pressure

          Systolic blood pressure

          The pressure on your artery walls with every heartbeat. In the trial, systolic BP fell 6.1 mmHg vs placebo for blood pressure already in the normal range.

          Not just made for longevity. Studied for it.

          NOVOS Core has been tested across the full arc of longevity research: DNA, cells, animal lifespan, epigenetic biological age, and placebo-controlled human research.

           

          Rapid, durable cardiovascular benefits.

          Cardiovascular · Randomized Human Trial

          In a randomized, double-blind, placebo-controlled trial in healthy adults aged 40+, NOVOS Core produced statistically significant improvements at six months in endothelial function, arterial flexibility, and systolic blood pressure (among participants already within the normal range).

          Up to 77% more DNA protection.

          Cells & DNA · In Vitro

          NOVOS Core ingredients supported DNA integrity by up to 77% in irradiated skin cells. The NOVOS combination outperformed its individual ingredients.

          In vitro study. Not indicative of human outcomes.

          18% longer lifespan.

          Lifespan · Animal

          In aged mice, NOVOS Core extended lifespan by over 18%, the highest yet recorded for an over-the-counter supplement in aged-mouse models.

          Animal study. Results may not translate to humans. Animal studies are not relied upon to support any representations of health benefit in humans.

          73% showed a slower pace of aging score.

          Biological Age · Case Study

          In a 12-participant case study (ages 39–76), 73% reduced their DunedinPACE score. No participant’s score increased.

          Case study, n=12; not a controlled trial. DunedinPACE is a research-use algorithm correlated with biological pace of aging, not a direct or definitive measure of aging. Individual results may vary.

          22% firmer skin.

          Skin Firmness · Pilot

          In a 6-month pilot (n=4), every participant improved skin firmness, averaging 22% (range 12% to 40%).

          Pilot study, n=4. Preliminary. Individual results may vary.

          Twelve ingredients in one daily formula.

          No proprietary blends. Every dose printed on the label. Patent pending.

          • Calcium Alpha-Ketoglutarate
          • Glycine
          • Pterostilbene
          • Fisetin
          • Malate
          • Magnesium
          • Glucosamine Sulfate
          • L-Theanine
          • Rhodiola Rosea
          • Hyaluronic Acid
          • Vitamin C
          • Ginger
          • Micro-dosed Lithium

          Customer reviews.

           Based on 1,331 ratings

          • Less Gray hair

            i have been taking it for 3 months now and i actually been noticing less gray hair. i thought i was going crazy thinking it was changing something in my gray hairs and looks like maybe i am not.

            Lindsay M.

          • One month in

            I’m coming up on my first month of core + boost—and it’s really already changing my energy levels. I just feel BETTER. I can’t wait to see the benefits at the 3,6, and 12 month mark!!

            Lisa H.

          • NOVOS Core Orange flavour

            Amazing product. I have a very senstive Gut. I always bloated after eating or without eating any meal. When if i feel bloated i drink novos core it helps me a lot !! my Gut starts to digest better!! I feel my brain functions better because no more bloating!!!

            Semhar

          • Fantastic product and fantastic…

            Fantastic product and customer service! I highly recommend the NOVOS line. I've taken them for 6 months and can see (skin) and feel (energy, well-being) the difference. I prefer the Orange flavored Core vs the unflavored version.

            Rick

            Questions, answered.

            Everything you need to know about NOVOS, the science, and getting started.

            When will I feel results?

            Many customers notice subtle changes in clarity and energy in the first few days. Broader changes (energy, sleep, skin) typically build over weeks to months. Biological-age changes develop over a longer horizon and depend on baseline health and consistent use. Individual results may vary.

            What’s in NOVOS Core?

            Twelve science-backed longevity ingredients in one daily drink mix. No proprietary blends, every dose disclosed.

            Is it safe with my other supplements or medications?

            NOVOS Core is formulated for tolerability and long-term daily use. If you take prescription medications or have a medical condition, share the ingredient list with your healthcare provider before starting.

            What does it taste like?

            Orange is a light citrus flavor, no artificial sweeteners. Tropical Passion is a bright passionfruit blend, equally light. Unflavored is neutral and disappears into smoothies, or any drink.

            What if I’m sensitive to supplements?

            Start with half a pack for the first week and build up. The formula is vegan, sugar-free, gluten-free, and free of artificial sweeteners. If sensitivities persist, consult your healthcare provider.

            Is NOVOS Core HSA/FSA eligible?

            Yes. NOVOS Core may qualify for HSA/FSA reimbursement through our partner Truemed. Look for the Truemed option at checkout.

            Who is NOVOS Core not for?

            NOVOS Core is designed for healthy adults. It is not intended for anyone under 18, or for those who are pregnant or nursing. If you have a medical condition or take medications, talk with your healthcare provider first.

            Where is it made?

            NOVOS Core is manufactured in the U.S.A. in cGMP facilities, using rigorously tested ingredients from trusted partners worldwide.